Cerebrolysin

Quick Facts

Full Name: Cerebrolysin (FPF-1070)
Aliases: Cere, FPF-1070, EVER Neuro Pharma product
Category: Neuroprotection / Neurogenesis / Dementia Treatment
Type: Mixture of low-molecular-weight neurotrophic peptide fragments (derived from porcine brain protein hydrolysate)
Molecular Weight: <10,000 Da (mixture of peptide fragments)
Administration: Intramuscular (IM) / Intravenous (IV)
Typical Dose: 5–10 mL/day IM or IV
Duration: 10–20 day cycles, typically
Status: Approved in several countries (Russia, China, EU); Research Only in USA/Canada
WADA Status: Not listed

What It Does

Cerebrolysin is a standardized mixture of neuropeptide fragments that mimics the combined action of multiple neurotrophic factors — BDNF, NGF, CNTF, and GDNF — providing broad neuroprotective, neurogenic, and neurotrophic support. It is approved for stroke rehabilitation and dementia treatment in numerous countries. Active peptide fragments cross the blood-brain barrier and directly modulate neuronal survival, synaptic plasticity, and neurogenesis. The parent compound for the P21 neurogenic peptide fraction.

Mechanism of Action

Multi-neurotrophic factor mimicry: Active peptide fractions (including P21) mimic BDNF, NGF, CNTF, and GDNF → comprehensive neurotrophic support without requiring full-size protein administration
BDNF and NGF upregulation: Promotes endogenous synthesis of both factors in hippocampus and cortex
Neurogenesis: Stimulates hippocampal and cortical neural stem cell proliferation → measurable increases in hippocampal volume
Anti-excitotoxic protection: Reduces glutamate-mediated neuronal injury; stabilizes calcium homeostasis
Anti-apoptotic signaling: Activates PI3K/Akt and MAPK/ERK survival pathways
Synaptic plasticity: Enhances LTP (long-term potentiation) → improved memory consolidation
Amyloid and tau modulation: Reduces Aβ aggregation and tau hyperphosphorylation in preclinical Alzheimer's models

Ageless Peps Products

APWS-Cerebrolysin-Vial — Cerebrolysin 60mg Vial, $25, wholesale only

Dosing Protocols

Standard Neurological Protocol

Dose: 5–10 mL IM or IV
Frequency: Once daily
Duration: 10–20 consecutive days
Rest: 1–3 months between courses
IM: Inject undiluted into gluteal muscle
IV: Dilute in 100–250 mL normal saline; infuse over 60–120 minutes
Source: The Peptides Bible, manufacturer protocols, Auer et al.

Performance / Cognitive Protocol

5 mL IM daily × 10 days; repeat quarterly
Stack with NSI-189 for additive neurogenesis

Stacks Well With

RG3 + NSI-189 – advanced neurogenesis and neuroprotection stack
Semax – BDNF + NGF multi-pathway cognitive stack
Selank – anxiolytic and BDNF complement
P21 – concentrated active peptide fraction of Cerebrolysin
BPC-157 – systemic healing and neuroprotection synergy

Use Cases

Stroke Recovery (post-stroke neurological recovery) — see Post-Stroke Recovery Protocol
Dementia and Alzheimer's Disease management
TBI Recovery (traumatic brain injury)
Cognitive Enhancement (healthy aging, performance)
Depression and treatment-resistant mood disorders
Neurogenesis and neuroplasticity optimization
Neuroprotection

Contraindications & Safety

Active malignancy — neurotrophic growth factors; caution
Epilepsy — seizure threshold may be affected; monitor
Renal impairment — slow IV administration; monitor
Porcine protein allergy — derived from pig brain; avoid in allergy
IV administration — must be diluted properly; rapid IV push contraindicated
Common side effects: Mild injection site reaction (IM), warmth/flushing during IV, dizziness; headache rare

Storage

Ampules: Room temperature; protect from freezing and light; 3-year shelf life
Once opened: Use immediately
IV diluted solution: Use within 24 hours

PubMed Research

Research links will be added after PubMed search

Sources

The Peptides Bible – Neurotrophic peptides section
Peptide Protocols Master Bible – Neurological rehabilitation protocols
Auer et al., J Neural Transm — stroke and Cerebrolysin research

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