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Curriculum / Mitochondria: Biology, Dysfunction & Therapeutics

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Mitochondria: Biology, Dysfunction & Therapeutics

The mitochondrion as an organ system and a therapeutic target — the electron transport chain, redox biology, and how mitochondrial dysfunction drives metabolic disease, sarcopenia, neurodegeneration and aging, then the therapeutic toolkit by functional axis: NAD⁺ and sirtuins, membrane protection (SS-31), the mitochondrial-derived peptides MOTS-c and Humanin, mitophagy (Urolithin A), and biogenesis mimetics.

10

lessons

10

knowledge checks

⌛

Pending Dr. Gross review

Awaiting board-certified physician sign-off

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Lessons

10 lessons, evidence-linked end to end.

Each lesson ends with a graded knowledge check.

1

The Mitochondrion: Anatomy, Bioenergetics, and the ATP Engine

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2

Reactive Oxygen Species, Redox Balance, and Oxidative Stress

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3

Mitochondrial Dysfunction: How the Engine Fails Across Disease and Aging

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4

NAD⁺ and Sirtuin Biology: The Central Redox Cofactor

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5

Raising NAD⁺: Precursors and 5-Amino-1MQ (NNMT Inhibition)

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6

Membrane and Redox Protection: SS-31 (Elamipretide)

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7

Mitochondrial-Derived Peptides: MOTS-c and Humanin

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8

Mitophagy and Quality Control: Urolithin A and the Mitochondrial Life Cycle

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9

Mitochondrial Biogenesis & Exercise Mimetics: PGC-1α, SLU-PP-332 & BAM15

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10

Building a Mitochondrial-Health Protocol: Candidacy, Lifestyle Levers, Integration & Safety

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